DMXE (deoxymethoxetamine, 3-Me-2’-oxo-PCE hydrochloride) is structurally very similar to MXE, with only the methoxy replaced with methyl (oxygen removed and hence the ‘deoxy’).
As with each iteration of our MXE analogues, we get closer and closer to the original. And whilst DMXE has its own unique and special properties, it is extremely similar to MXE. As we demonstrated with 3-Me-PCP, the 3-MeO group can be substituted with methyl without loss of potency or significant alteration of pharmacological profile. We are pleased to see that the 2’-oxo compounds follow the same SAR (Structure–activity relationship), from the several we have synthesised, including DMXE.